Moreover, several groups reported that the contribution of VLA-4 on monocyte/macrophage infiltration into the sub-endothelial space of blood vessels might be partial [1,2,42] and that ICAM-1/β2-integrin interaction plays a key role in macrophage accumulation in inflammatory conditions, including atherosclerosis [2,3,4,5,6,7]. This evidence concerns the gene ICAM1 and atherosclerosis.