PI3 and neuropathy: As an example of this, Miyashita et al. [73] described potential therapeutic interventions for neuropathy by manipulating genes such as insulin, GLP-1, PTEN, HSP27, RAGE, CWC22, and DUSP1 via the phosphatidylinositol-3 kinase/phosphorylated protein kinase B [PI3/pAkt] signaling pathway by utilizing oligonucleotids.