APOA5 and hypertriglyceridemia: Turning attention to Apo-A5, a pivotal player in reducing the TG levels in plasma by enhancing LPL activity, investigations highlight a nuanced correlation between the abundance of specific microbial species (such as the Porphyromonadaceae family, including the Parabacteroides genera, the Rikenellaceae family, and Odoribacter genus) and Apo-A5 polymorphisms, which are intricately associated with the manifestation of hypertriglyceridemia and reductions in Actinobacteria such as Bifidobacterium [22].