No evidence for the presence of anti-idiotypic TCRs in T1DM or AM appears to exist, but indirect evidence comes from the fact that the TCRs mimic both actin and myosin (which combine to form actinomyosin), as well as collagen IV and laminins (which combine to form the extracellular matrix; Table 2). This evidence concerns the gene LAMB2 and type 1 diabetes mellitus.