Some of these genes were also described in different works regarding UM [51], while two of them (CHL1 and IL12RB2) were also found to be hypermethylated with low expression in invasive malignant melanoma cells [52]; in particular, CHL1 is in an hypermethylated region on 3p in TCGA class 2 UMs [53]. Here, IL12RB2 is linked to melanoma.