Similarly, Mandel-Brehm et al. reported that patients with ROHHAD-NET syndrome were positive for anti-ZSCAN1 autoantibodies [10] and that anti-ZSCAN1 autoantibodies were mainly observed in patients with tumors such as ganglioneuroblastoma, ganglioneuroma, and neuroblastoma, although one patient was positive for autoantibodies even in the absence of a tumor. This evidence concerns the gene ZSCAN1 and rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome.