ZSCAN1 and rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome: Using a quantitative custom-made ELISA for the detection of anti-ZSCAN1 autoantibodies, we found that over 85% of the patients with ROHHAD syndrome without an NET exhibited a positive response to the anti-ZSCAN1 autoantibodies compared with that of the normal subjects.