Some of the phytoconstituents found in the Okinawan diet, such as resveratrol (which activates sirtuins and FOXO-3, linked to the IGF-1 pathway), genistein (contained in tofu, acting on FOXO-3), isoflavone (acting on pathways involved in apoptosis in human tumour models), and curcumin (acting on the NF-κB pathway), are associated with the concept of longevity. The gene discussed is FOXO3; the disease is neoplasm.