HIF1A and neoplasm: ISO treatment inhibited many canonical pathways, including “Tumor Microenvironment Pathway” (p-value = 6.68 × 10−7), “HIF1α Signaling” (p-value = 6.68 × 10−5), and “Actin Cytoskeleton Signaling” (p-value = 3.5 × 10−4), whereas the only highly activated molecular pathway was “Interferon Signaling” (p-value = 7.58 × 10−7) (Figure 3C).