Top KEGG pathways that were enriched in ISO-downregulated genes were Biosynthesis of amino acids (p-value = 5.59 × 10−7), HIF-1 signaling pathway (p-value = 1.67 × 10−8), Glycolysis/Gluconeogenesis (p-value = 3.32 × 10−5), Central carbon metabolism in cancer (p-value = 2.51 × 10−4), Focal adhesion (p-value = 2.60 × 10−8), Regulation of actin cytoskeletons (p-value = 3.51 × 10−4), and PI3K-Akt signaling pathway (Figure 5A). The gene discussed is HIF1A; the disease is cancer.