MAP2K1 and cancer: Many TME-related genes (such as VEGFA, MMP14, CCND1, MAP2K1, SLC2A1) (Figure 3D) and actin cytoskeleton-associated genes (such as ITGB4, ITGA6, ACTG1, VCL) (Figure 3E) were downregulated, suggesting a less favorable TME and an altered cytoskeleton network in ISO-treated cancer cells.