TNF and cancer: Other cancer-related KEGG terms such as Metabolic pathways (p-value = 5.90 × 10−6), Cytokine–cytokine receptor interaction (p-value = 3.0 × 10−3), and TNF signaling pathway (p-value = 7.03 × 10−3) were also enriched in ISO-upregulated genes, which was consistent with our GO analysis (Figure 4B and Figure 5B).