To assess the role of each of the two thrombospondins in the cellular processes that marked the progression of iCCA, we treated the CCLP1, an established human cell line of iCCA, with either human THBS1 or THBS2 in their recombinant form (rhTHBS1 and rhTHBS2). This evidence concerns the gene THBS1 and infantile convulsions and choreoathetosis.