Consistent with this, PTCy in humanised NSG mice [27] or P2X7 antagonism with pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid [12] in allogenic mice reduces GVHD without comprising GVL immunity to human THP-1 AML or murine A20 lymphoma cells, respectively. The gene discussed is P2RX7; the disease is graft versus host disease.