SNCA and Parkinson disease: Further substantiating the link between hypoxia/ischemia and PD, a recent study demonstrated that the induction of transient focal ischemia by middle cerebral artery occlusion in PD-model mice (expressing human alpha-synuclein with a known mutation leading to familial PD; A53T) led to progressive alpha-synuclein pathology and ultimately, the loss of dopaminergic neurons in the substantia nigra [65].