A list of markers associated with pyroptosis in HCC was published, which includes BAK, BAX, caspase 1, 3 and 5, gasdermin A and E, high-mobility group box 1, interleukin 18, 1A and 1B, p53, tumor protein 63, among others [135,136]. The gene discussed is TP53; the disease is hepatocellular carcinoma.