Let-7-5p-family miRNAs have been described as negative regulators of the pro-inflammatory and tumoricidal activity of “M1” macrophage tumor-associated macrophage (TAM) phenotypes (in contrast with the M2 phenotype with immunosuppressive and tumor-promoting activity), suppressing interferon (IFN)-γ-induced and immunostimulatory macrophage programming in cancer [50], and a luciferase reporter assay has demonstrated that T Cell Factor 4 (TCF-4) was a target of let-7a/b in head and neck squamous cell carcinoma [51]. Here, TCF7L2 is linked to head and neck squamous cell carcinoma.