AKT1 and triple-negative breast carcinoma: miR-4649-3p has been identified as a tumor suppressor in triple-negative breast cancer by targeting PIP5K1C, an Akt activator [76], while miR-615 targets the NK group 2 (NKG2) family receptor or TNF-α from immune cells, leading to diminished cytotoxic activity against tumor cells [77].