O. Delattre et al. reported the most frequent translocation t(11;22)(q24;q12) in Ewing sarcoma in 1992, producing the fusion between EWSR1 and the ETS (E twenty-six) transcription factor FLI1 (Friend leukemia integration 1) in their work [7]. This evidence concerns the gene EWSR1 and Ewing sarcoma.