P2RX7 and mastocytoma: These results further establish P2X7 as the main receptor for ATP-mediated degranulation in humans, confirming previous findings obtained using MCs from different tissues and species or cell lines such as the LAD2 cell line, mouse BMMCs, mouse peritoneal and meningeal MCs, mouse mastocytoma cells (P815), and MCs from rat spinal cords [16,17,30,54,55,56].