Intriguingly, both miR8126 isoforms downregulated QKI and MAPKAPK2 gene expression in the HepG2 model that mimicked hepatic steatosis, despite prediction algorithms reporting that miR8126-3p could target QKI and miR8126-5p could target MAPKAPK2, and not vice versa. The gene discussed is MAPKAPK2; the disease is fatty liver disease.