ACE and congestive heart failure: According to the most recent chronic heart failure guidelines, in patients with reduce ejection fraction, the recommended treatment comprises the following oral medicines [36]: angiotensin-converting enzyme inhibitor (ACE-I), or angiotensin-receptor blocker (ARB), angiotensin receptor-neprilysin inhibitor (ARNI), Beta-blocker, mineralocorticoid receptor antagonist (MRA), Dapagliflozin/Empagliflozin (SGLT2), and loop diuretics when indicated.