IGHE and eosinophilic esophagitis: As regards EoE, IL-4 and IL-13 are involved in favoring the releasing of eotaxin (CCL26) by esophageal epithelial cells, leading to eosinophils recruitment [24], Th2 differentiation, B cell IgG1 and IgE class-switching, and in epithelial to mesenchymal transition with consequent fibrosis [11,25].