TGFB1 and eosinophilic esophagitis: Regarding mast cells, although their concentration in the esophageal mucosa and their release of transforming growth factor β1 (TGF-β1), tryptase, leukotrienes, prostaglandins, and histamine have been proven, the trigger of their activation in EoE is still unknown, likely not to be recognized in IgE.