EoE is a Th2 disease characterized by a dysregulated inflammatory cascade in response to dietary and, to a lesser extent, aero-allergens, stimulating epithelial cells to secrete alarmins (cytokines including, i.e., IL-25, IL-33, and thymic stromal lymphopoietin TSLP), which promote the generation of Th2 cells and the activation of epithelial, dendritic, and other immune cells residing in the esophageal mucosa [10]. This evidence concerns the gene TSLP and eosinophilic esophagitis.