The strongest AMD genetic association in the complement system identified to date was reported in the common p. Tyr402His (rs1061170) variant in the complement factor H (CFH) gene [19,20,21,22], which is a missense coding SNP (C>T) and the most common AMD-related variant reported in the literature with the following allele frequencies: C = 0.32133 and T = 0.67867. The gene discussed is CFH; the disease is age-related macular degeneration.