In this context, several studies have shown that eTat is involved in the pathogenesis of Kaposi’s sarcoma (KS), an angio-proliferative tumor arising with high frequency in HIV infection (AIDS-KS) in a background of CD8 T cells activation, increased expression of Th1 cytokines, particularly IFN-γ, and ECs activation and dysfunction [120,121]. The gene discussed is IFNG; the disease is Kaposi's sarcoma.