PEDF has recently attracted a great deal of attention in terms of its metabolic regulation, and its circulation level has been reported to act as a biomarker for the severity of various metabolic diseases [11]: in healthy individuals aged 50 years and over, higher serum PEDF levels were observed in women, possibly reflecting their comorbidities and estrogen statuses [12]. The gene discussed is SERPINF1; the disease is Other metabolic disease.