PATJ and epilepsy: Many more components that control BBB pathophysiological properties need to be studied, including components of the neurovascular unit such as extracellular matrix proteins, tight junction associated proteins, etc. Some general principles are starting to emerge, raising the hope that a better understanding of BBB dysfunction in CNS diseases will help towards characterization of the mechanisms that control vascular integrity, the basis of BBB dysfunction during epilepsy, and the development of new therapeutic strategies.