CB2 receptor activation by curcumin significantly reduced the inflammatory response by depleting the synthesis of IL-1β in cardiomyocytes; on the other hand, the CB2 receptor blockade by AM630 significantly attenuated the effect of curcumin in isoproterenol-induced MI in diabetic mice, which indicates an anti-inflammatory effect of the CB2 receptor in cardiovascular diseases [38]. Here, IL1B is linked to myocardial infarction.