RPS6KB1 and diabetic cardiomyopathy: According to earlier research, when the CB2 receptor was selectively activated with HU308, it had a cardioprotective impact over diabetic cardiomyopathy and shielded the cardiomyocytes from the damaging effects of high glucose by activating autophagy through the AMPK–mTOR–p70S6K signaling pathway [80].