MMP2 and retinoblastoma: Since MMP2 has been identified to be secreted by the cytotrophoblast cells that are responsible in digesting the major constituents of the endometrial matrix [27] and has been demonstrated to be a direct target of FOXM1 in retinoblastoma cells [28], we also evaluated the mRNA expression of MMP2 following gain (p = 0.03) and loss (p = 0.03) of FOXM1 expression.