CXCL8 and type 2 diabetes mellitus: In patients with T2D, we also observed a significant increase of circulating IL-6 (2.2-fold, p < 0.001), IL-8 (2.7-fold, p < 0.001), and CRP (1.8-fold, p < 0.01), which are known for their capacity to induce NETosis [25,37,38] (Figure 2D–F).