ATM Ser49Cys, GOLM1 Ser307Leu and MITF Glu318Lys all occur in higher frequencies in melanoma-affected populations (2.3%, 2.9% and 1.6–2.8%, respectively) as compared to general populations (~0.2% and 0.6–0.8%, respectively) [25,26]. The gene discussed is GOLM1; the disease is melanoma.