We also determined the spatial expression of proinflammatory cytokines TNFα and IFNγ, as well as immune regulators, including inducible nitric oxide synthase-2 (NOS2), glutathione reductase (GR), and glutathione S-transferase M3 (GSTM3), all of which are involved in TB pathogenesis. This evidence concerns the gene TNF and tuberculosis.