GPBAR1 and Parkinson disease: Wang et al. observed that the takeda G protein-coupled receptor 5 (TGR5) inhibitor triamterene could reduce the anti-neuroinflammatory effect of bear bile powder on LPS-stimulated rat C6 astrocytic cells, suggesting that bear bile powder’s protective effects on PD mice may threaten astrocyte-mediated inflammation via TGR5 [191].