Based on these potential mechanisms underlying PD, various anti-inflammatory therapies (i.e., NLRP3 inflammasome inhibition, NF-κB inhibition, microglia inhibition, astrocyte inhibition, NADPH oxidase inhibition, PPARγ agonist, targeting MAPK pathway, targeting AMPK-dependent pathway, targeting α-synuclein, targeting miRNAs, acupuncture, exercise, NSAIDs, etc.)were explored to alleviate the disease. This evidence concerns the gene NFKB1 and Parkinson disease.