AIF1 and Parkinson disease: The utilization of icaritin and its glucoside in PD mice induced by MPTP or 6-OHDA lessens DA neuronal harm, reduces the secretion of pro-inflammatory cytokines, and inhibits the protein expression of ionized calcium-binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) in the brain through impeding NLRP3 inflammasome activation and spurring the production of kelch-like ECH-associated protein 1 (Keap1), HO-1, Nrf2, and NADPH quinone dehydrogenase 1 (NQO1) proteins [154,155].