Analyses of the immune histochemical procedures conducted on patients with PD demonstrated an elevated translocation of NF-κB in the nucleus of the mesencephalic DA neurons, which in turn triggered the transcription of pro-inflammatory mediators (chemokines, cytokines) and the formation of ROS through auto-oxidation and enzymatic dopamine catabolism [96,97,98]. The gene discussed is NFKB1; the disease is Parkinson disease.