Although most small molecules have been shown to modulate the stability of the MALAT1 triple helix in a test tube, the aromatic imidazole-derived compound 5 decreases endogenous MALAT1 by 54% in MMTV-PyMT tumors and 38% in mammary tumor organoid branching, while MENβ levels do not change significantly [23]. This evidence concerns the gene MALAT1 and breast cancer.