MALAT1 and neoplasm: Importantly, MALAT1 is upregulated, most notably in leader cells, and the knockdown of MALAT1 using antisense oligonucleotides (ASOs) reduces invasiveness in bladder cancer cells, as well as metastasis, organoid branching and the growth of the tumor in MMTV-PyMT (mouse mammary tumor virus–polyoma middle tumor antigen) mouse mammary carcinoma model [11,12].