Therefore, LEF1 could be an important transcriptional factor related to the aggressive features of EOC, while the expression of CSPG4 and CSPG4 in ovarian cancer cells is predicted to activate the FAK pathway through its interaction with FN1 and promote the migration and invasion of ovarian cancer cells via downstream signaling (PI3K/Akt). This evidence concerns the gene LEF1 and ovarian cancer.