It has been also demonstrated that the injection of up-regulated exosomal miR-17-3p contained in sEVs from human umbilical cord mesenchymal stem cells, reduced blood glucose and HbAlc levels, increased body weight, Hb content and the glutamine synthetase level, decreased the contents of inflammatory factors and VEGF, alleviated oxidative injury, and inhibited retinal cell apoptosis in an experimental mouse diabetes model, through inhibiting signal transducers and activators of transcription 1 (STAT1) [88]. The gene discussed is STAT1; the disease is diabetes mellitus.