LRRFIP1 and dyskeratosis congenita: Given that the LRRFIP1 and PTMA genes are situated at the distal end of the q arm of chromosome 2, and considering that telomere dysfunction and shortening are defining characteristics of DC, it is conceivable that these chromosomal regions in DC patients are highly susceptible to rearrangements as a consequence of telomere dysfunction-driven genomic instability.