We recently performed a social reward-conditioned place preference (SCPP) test using AKR-, BALB/c-, and C57BL/6J-strain mail mice and found significant anxiety-like and anhedonia-like behaviors in BALB/c mice with downregulation of GR in the nucleus accumbens (NAC), compared with those in AKR and C57BL/6J strains [25]. This evidence concerns the gene NR3C1 and Anxiety.