ITIH1 and cancer: Among the up-regulated proteins in EVs were ITIH1, 2, and 3 proteins, belonging to the family of inter-α-trypsin protease inhibitors, which stabilize the extracellular matrices by binding hyaluronic acid, thus exerting anti-metastatic effects in cancer [42], and RBP, which stimulates macrophages’ polarization in cancer models [43].