PRAME and Merkel cell skin cancer: Also, its expression seems to vary quite vastly among the reported studies, with some showing a strong and diffuse PRAME expression in basal cell skin carcinomas and, more infrequently, in Merkel cell carcinomas (MCCs) [13], while others show a negative or low-intensity PRAME expression in a small percentage of NMSCs, except for some MCCs showing high-intensity and diffuse staining [26].