The development of sensitive and specific assays to detect PRAME expression may be useful for selected diagnostic problems: the distinction of nevus from melanoma (in skin or lymph nodes) and the assessment of the margin clearance of melanomas, particularly in cases with a lentiginous in situ component such as seen in acral and lentigo maligna melanomas, enabling early intervention and improving patient outcomes [4]. The gene discussed is PRAME; the disease is melanoma.