Furthermore, despite the association between increased PRAME expression, the presence of pathogenic NRAS mutations, and a worse prognosis in mucosal melanomas, PRAME expression does not appear to correlate with the presence of NRAS mutations, suggesting that although both factors taken individually may be associated with worse outcomes, they may act independently in the context of mucosal melanomas [39]. The gene discussed is PRAME; the disease is mucosal melanoma.