For instance, high levels of PRAME expression have been documented in cutaneous melanoma, which is where the antigen was first discovered [8,19], but it has since been found to be expressed in various malignancies, including leukaemia [7], neuroblastoma [20], non-small-cell lung cancer [21], breast cancer [22], ovarian cancer [23], and various sarcomas [24,25]. The gene discussed is PRAME; the disease is leukemia.