A high body mass index, identifying overweight and obesity conditions, has been associated with a marked survival advantage after both targeted and immunotherapy in male melanoma patients [34], highlighting a potential link between factors associated with obesity, such as free FA, insulin/IGF1, and proinflammatory cytokines, and the activation of an effective anti-tumor immune response. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.