A high body mass index, identifying overweight and obesity conditions, has been associated with a marked survival advantage after both targeted and immunotherapy in male melanoma patients [34], highlighting a potential link between factors associated with obesity, such as free FA, insulin/IGF1, and proinflammatory cytokines, and the activation of an effective anti-tumor immune response. This evidence concerns the gene IGF1 and obesity due to melanocortin 4 receptor deficiency.