In the second model, in which alcohol binges were used to cause ACLF while CLD was induced using a toxic approach, again, intrahepatic HIF-1α mRNA expression was significantly increased in ACLF, but not in CLD, again accompanied by increases in NFκB1 and STAT3 mRNA levels. The gene discussed is NFKB1; the disease is congenital secretory chloride diarrhea 1.