Here, a significantly increased amount of HIF-1α mRNA was observed in the skeletal muscle (both CLD and ACLF) and small bowel tissue (increase in CLD, non-significant decrease in ACLF, Figure 4A), while other extrahepatic organs (brain, heart, kidney, lung, spleen) did not show this phenomenon. Here, HIF1A is linked to congenital secretory chloride diarrhea 1.