GPBAR1 and irritable bowel syndrome: The association between the TGR5 SNP rs11554825 (minor allele frequency 41%) and symptom phenotype (total cohort), as well as intermediate phenotype (SBT or colonic transit assessed through radioscintigraphy), was investigated in a sample comprising 230 healthy controls and 414 patients with lower functional gastrointestinal disorders (FGID), including IBS-alternators [Alt] (n = 84), IBS-constipation [IBS-C] (n = 157), and IBS-D (n = 173).