Importantly, FB from TRPV4+/+ mice of the HF(iso) groups pre-incubated with the TRPV4 antagonist HC067047 (10 μM) showed mitigated Ca2+ influx in response to either GSK1016790A (Figure 4B, bottom) or hypotonic stress (Figure 4C, bottom). Here, TRPV4 is linked to hydrops fetalis.