Four T2D archetype profiles in newly diagnosed individuals were recently identified based on differences in disease progression, genetic risk scores, and circulating omics biomarkers (Figure 1) and they were: (1) lean and insulin deficient, (2) obese and insulin sensitive, (3) obese and IR, and (4) a severe phenotype with obesity, IR, dyslipidemia, and impaired β-cell glucose sensitivity that progresses rapidly to frank T2D that required the most anti-diabetic interventions [4]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.