Exosomes from R patients, those exhibiting a clinical improvement of liver steatosis, were found to decrease α-SMA, COL1A1, Vimentin, and EGFR expressions by LX-2 cells (stellate cells), leading to a decrease in the extracellular matrix (ECM) protein deposition and fibrosis. This evidence concerns the gene ACTA1 and Hepatic steatosis.