TNF and keloid: By using a whole genome-wide linkage search, they identified D2S1399 on chromosome 2, linked to the gene for tumor necrosis factor alpha (TNFα) inhibitory protein 6 (TNFAIP6) in the Japanese keloid family, and D7S499 at chromosome 7, linked to the gene for epidermal growth factor receptor (EGFR) in the African-American keloid family, as susceptible loci for keloid formation in two families with an autosomal dominant inheritance pattern of keloids [17].