Various cytokines are involved in NETosis in ALI/ARDS, such as IL-8, which has been found to be associated with NET concentration in bronchoalveolar lavage fluid (BALF) in ARDS patients [91], and IL17A, which may synergistically induce NET production through STAT3 activation with other cofactors [92]. This evidence concerns the gene STAT3 and acute respiratory distress syndrome.