ANA12 (N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide) is a small-molecule TrkB (tyrosine receptor kinase B) receptor antagonist that transiently blocks BDNF (brain derived neurotrophic factor)-TrkB activation during the pathogenesis of HIE [8,9,10]. This evidence concerns the gene BDNF and perinatal asphyxia.