IL5 and infection: Additional studies on helminth infection have identified group 2 innate lymphoid cells (ILC2s) as a major component of type Th2 innate responses to infections responsible for IL-5 and IL-3 secretion that induce goblet cell division, increase in mucus secretion, smooth muscle contraction, eosinophil and mast cell recruitment and alternative macrophage activation [37,64,69].