Further, GT-00AxIL15 exerted enhanced anti-tumor cytotoxicity compared to its parental mAb GT-00A and an untargeted MOPCxIL15 isotype control, which is mediated by TA-MUC1-targeting in combination with increased effector cell-mediated cytotoxicity induced by the IL-15 modules. Here, IL15 is linked to neoplasm.