In contrast, pediatric patients, who mostly present with CM, may exhibit a mutation of codon 816 in exon 17 in approximately 42% (including the KIT D816V mutation in 36%), as well as different somatic or germline KIT mutations, mainly in exons 8, 9, and 11 (approximately 44%), or have no KIT mutation (wild-type genotype, approximately 14%) [16,18]. This evidence concerns the gene KIT and cutaneous mastocytosis.