The expression of ECM components, including Collagen I, fibrinogen, Desmin and Vimentin was weakly spread among both the different immune cell clusters and the PDGFRβ+, αSMA+ stromal cells cluster, thus suggesting that TME−constituting cells were immersed in the tumor ECM, some of these with (uPA/uPAR) fibrinolytic activity of remodeling of the coagulative stroma (Figure 6D). This evidence concerns the gene DES and neoplasm.