The correlation analysis of the expression of these two complement proteins (C3 and IGHM) from the Nephroseq datasets retrieved positive statistically significant results (Woroniecka Diabetes TubInt GSE30529 [23] p = 0.0001, r = 0.735; Woroniecka Diabetes Glom GSE30528 [23] p = 0.0002, rs = 0.706; Ju CKD TubInt GSE47184 [37] p = 0, rs = 0.46). Here, C3 is linked to chronic kidney disease.