Six genes, including CASP3, GSDME, NLRC4, NLRP6, NOD1, and PLCG1, were found to be correlated with the OS rate of HCC patients, with GSDME, NLRP6, and NOD1 significantly correlating with a worse prognosis, particularly in pTNM stage III–IV. Here, GSDME is linked to hepatocellular carcinoma.